Iran’s supreme leader has denounced a proposal by the United States aimed at curbing Tehran’s nuclear efforts and demanded that his country retains national independence amid reports of Washington offering to become involved in Tehran’s nuclear program.

An outline by the Trump administration would allow Iran to continue enriching uranium at low levels while a broader arrangement is worked out that would block the country’s path to a nuclear weapon.

Iran's Supreme Leader Ayatollah Ali Khamenei said on Wednesday that abandoning uranium enrichment was "100%" against the country's interests, rejecting a central U.S. demand in talks to resolve a decades-long dispute over Tehran's nuclear ambitions.