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Pregame analysis and predictions of the Pittsburgh Pirates vs. Chicago Cubs MLB game to be played on June 15, 2025 on ESPN.

Andrew McCutchen, the second batter of the game, homered to give the Bucs a 1-0 lead early. It was McCutchen’s 32nd career homer against the Cubs, which ties him for second-most among active players with Paul Goldschmidt. Eugenio Suárez leads with 36.

Pirates ace Paul Skenes struck out five in five scoreless innings. Skenes was matched by Cade Horton, who permitted three hits in 5 2/3 shutout innings.

The Pittsburgh Pirates defeated the Chicago Cubs 2-1 in 10 innings on Friday afternoon at Wrigley Field. Paul Skenes took a no-decision after throwing 5.0-shutout innings and Isiah Kiner-Falefa drove in the game-winning run on a sac fly in the top of the 10th.

The Pittsburgh Pirates changed their lineup ahead of their next game vs. the Chicago Cubs, who bring in a left-handed pitcher. Cubs will have left-handed pitcher Matthew Boyd make the start vs. the Pirates at Wrigley Field,

Defense and quality pitching helped get the Pirates to extra innings Friday afternoon at Wrigley Field, setting up Isiah Kiner-Falefa to drive home the winning run and propel the Bucs to a 2-1 win over the Cubs.