The Rams vs. 49ers game kicks off at 4:25 p.m. ET/1:25 p.m. PT this Sunday, Nov. 9, 2025. The Week 10 game between the Rams and 49ers will air on FOX. Out-of-market, you can tune in via NFL Sunday Ticket on YouTube TV.

Quarterback Brock Purdy returns to the starting lineup for the San Francisco 49ers this week after missing six games with a toe injury.

Rams quarterback Matthew Stafford threw for four touchdowns, and inside linebacker Nate Landman and cornerback Emmanuel Forbes Jr. added to their takeaway totals in the team's Week 10 win over the 49ers at Levi's Stadium.

The Week 10 loss to the Los Angeles Rams was by far the worst of the season for the San Francisco 49ers.

In Sunday's dreadful 42-26 loss to the Los Angeles Rams, it's possible that ailing linebacker Dee Winters best symbolized the San Francisco 49ers' struggle on defense.

It’s ok to be frustrated over the 49ers’ loss. Just tell yourself that at the very least the 49ers aren’t the Cardinals.

WOODLAND HILLS, Ca. The Los Angeles Rams defeated the San Francisco 49ers on Sunday, resulting in their first division win of the season and keeping them tied for first place in the NFC West with the Seattle Seahawks. Before the game, I made five bold predictions for the Rams. Let's see the results.

Christian McCaffrey #23 of the San Francisco 49ers runs with the ball during the game against the Los Angeles Rams at Levi’s Stadium on November 9, 2025 in Santa Clara, California. Matthew Stafford #9 of the Los Angeles Rams throws during the game against the San Francisco 49ers at Levi’s Stadium on November 9, 2025 in Santa Clara, California.