Patrick Dempsey's Dr. Derek Shepherd's death in Grey's Anatomy was a huge event for the show and pop culture, marking a turning point in the story for Ellen Pompeo's Dr. Meredith Grey. Grey's Anatomy ...

Fans had no idea about the impact the terminology "McDreamy" had on television viewers in the 2000s and the chemistry was off the charts when Meredith Grey and Derek Shepherd first made contact.