“Novel senomorphic and senolytic agents can be evaluated in this model as they are identified.” Idiopathic pulmonary fibrosis (IPF) is an age-related disease with poor prognosis and limited ...

Blood tests, ultrasounds, and MRIs often fail to detect the earliest changes in cardiomyopathy, when fibroblasts activate and start the scarring process. Since early detection is crucial for the best ...

Figure 1. Maximum-intensity projections and fusion images of [68 Ga]Ga-FAPI PET/CT from representative patients of different NICM subtypes. PET scans were classified into three columns, including ...

NUDT21 regulates fibroblast senescence and is significantly decreased in aged and fibrotic lungs, impacting IPF progression. Alternative polyadenylation (APA) and NUDT21 downregulation enhance STAT3 ...

A new molecular imaging technique -- 18F-FAPI PET -- can detect the first signs of tissue remodeling in patients with pulmonary arterial hypertension (PAH), providing physicians with an early marker ...

Cardiovascular disease often culminates in heart failure, a hallmark of which is fibrosis, a form of tissue scarring. Cardiac fibrosis initially repairs damaged heart tissue, but it can quickly become ...

Metabolic reprogramming in fibrotic lung diseases involves key metabolites like lactate, succinate, and 2-hydroxyglutarate, driving inflammation and fibroblast activation. Lactate accumulation ...

In recent years, interest has grown around two investigational peptides, BPC-157 and TB-500, proposed as part of a combined research-oriented protocol to explore tissue regeneration, angiogenesis, and ...

Fibroblast activation protein (FAP) is a serine protease, the expression of which increases with pathogenic fibroblasts in the fibrotic liver during metabolic dysfunction-associated steatohepatitis ...

A new PET/CT imaging technique that visualizes activated fibroblasts in the heart muscle enables early detection of multiple forms of cardiomyopathy, according to research presented at the Society of ...