A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G protein-coupled receptors (GPCRs). This research offers ...

G protein-coupled receptor kinase 2 (GRK2) has emerged as a pivotal regulator in the pathophysiology of heart failure. GRK2 mediates the phosphorylation of activated G protein‐coupled receptors (GPCRs ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

GPCRs are the largest receptor class, affecting almost every aspect of human physiology, with 35% of all approved drugs acting on GPCRs. They regulate sensory and neuronal signaling, as well as a ...

G protein-coupled receptors (GPCRs) are essential for cell signal transduction and comprise the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple ...

Structure and the tethered activation mechanism of aGPCRs. (A) The basic structure of aGPCRs. This article highlights the critical role of mechanosensitive aGPCRs in human health and disease, setting ...

Lefkowitz started to trace cell receptors in 1968. Using radioactivity, he managed to unveil several receptors, including one for adrenalin, the β-adrenergic receptor. His team then extracted the ...

A publication from Acta Pharmaceutica Sinica B discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a debilitating ...

A preliminary study of people with diabetes suggests that use of glucose-lowering GLP-1 drugs may be linked to a lower risk of developing epilepsy. The study was published in Neurology. A systematic ...

Kaplan-Meier methods estimated overall survival (OS) and duration of response (DOR). DOR was defined from the time of initial response to progression, death, or last follow-up. Median follow-up was ...

Many people are familiar with histamine, a biological molecule that serves as a key driver of allergic reactions and other immune responses. However, histamine is also a major neurotransmitter in the ...