Cryo-EM revealed HIV-1 integrase’s distinct structures as it shifts between its two roles of DNA integration and RNA-binding.

LA JOLLA, Calif., June 26, 2009 – Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce ...

A new technique allows researchers to simultaneously monitor RNA, DNA, and protein trafficking during HIV’s replication cycle. Immunofluorescent visualization of viral RNA and viral proteins in ...

Despite the success of protease and reverse transcriptase inhibitors, new drugs to suppress HIV-1 replication are still needed. Several other early events in the viral life cycle (stages before the ...

Viruses lurk in the grey area between the living and the nonliving, according to scientists. Like living things, they replicate but they don't do it on their own. The HIV-1 virus, like all viruses, ...

A new antiretroviral target has been identified that suppresses HIV-1 replication and selectively kills HIV-1-infected cells. HIV-1 is the most common type of HIV. When HIV-1 leaves infected cells, ...

University of Virginia School of Medicine scientists have uncovered a key reason why HIV remains so difficult to cure: Their research shows that small changes in the virus affect how quickly or slowly ...

For instance, targeted antiviral drug development did not begin with HIV infection. However, significant investments in biomedical research, supported by the NIH, and in drug development, supported by ...

Researchers at Johns Hopkins Medicine, in collaboration with researchers at the National Institutes of Health, report that two new studies in mice with a humanized immune system and human cell lines ...

During the last 20 years, a myriad of cellular proteins with various functions have been identified as capable of hindering different steps in the HIV life cycle. This effect is particularly strong ...

Gene silencing is a mechanism mediated by short interfering RNAs (siRNAs), which suppress the activity of particular genes at certain places or times. In plants this process has an antiviral defense ...