The objective of this study was to define the maximum-tolerated dose (MTD), the recommended phase II dose, the dose-limiting toxicity, and determine the pharmacokinetic (PK) and pharmacodynamic ...

Valproic acid (VPA), primarily known as an antiepileptic drug, has recently transcended its conventional role owing to its function as a histone deacetylase inhibitor (HDACI). By inhibiting histone ...

This is a preview. Log in through your library . Abstract The yellow fever mosquito, Aedes aegypti, is distributed worldwide and transmits viruses that cause many diseases, including dengue, yellow ...

The FDA has approved Duvyzat for the treatment of Duchenne muscular dystrophy among patients aged 6 years and older, according to a press release. Duvyzat (givinostat, Italfarmaco) is a histone ...

Safety and Efficacy of Osimertinib in Patients With Non–Small-Cell Lung Cancer and Uncommon Tumoral Epidermal Growth Factor Receptor Mutations: A Systematic Review and Single-Arm Meta-Analysis ...

Fruit ripening determines shelf life and consumer appeal, yet the molecular switches that control this process remain partially understood. This study identifies a key regulator—histone deacetylase ...

The FDA approved Duvyzat (givinostat), a novel histone deacetylase (HDAC), for the treatment of patients six years of age and older with Duchenne muscular dystrophy (DMD). This approval marks an ...

Histone deacetylases (HDACs) help control how accessible DNA is to the transcription machinery of the cell. They were the first enzymes to be targeted by drugs trying to affect cellular epigenetics, ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

In a recent study published in Nature Communications, researchers reported on stromal class I histone deacetylase (HDAC) inhibition to curb pancreatic cancer progression. Study: Inhibiting stromal ...