Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

DNA replication is the process by which a cell makes an identical copy of its DNA. This process is performed at the beginning of every cell division so that when the cell divides, each daughter cell ...

In eukaryotic cells, DNA polymerase (Pol) ε and Pol δ synthesize the leading and lagging strands, respectively 1,2. These enzymes work in the 5′-to-3′ direction, resulting in continuous replication of ...

Copy number variants (CNVs) are strongly implicated in neurological and psychiatric disorders and brain cancer, yet the process by which replication stress generates CNVs—and why some recur while ...