In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.

NFL expectations are never more skewed than early in the season. Perhaps that's why Week 1 underdogs thrive. Jason Logan returns for another year of his "NFL Underdogs" column, only picking teams getting the points. In life and football, managing expectations is the key to success.

NFL Week 1 is here! And if you are partaking in a confidence pool or pick 'em contest, Nick Kostos has you covered.