This week, we are going to discuss a condition that occurs after trauma and surgery as well as after traumatic injuries to the head, neck and spine. The condition? Heterotopic ossification.

In a new study published in Bone Research, a team of researchers from Johns Hopkins University and colleagues, using a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq), has ...

Heterotopic ossification (HO) refers to the pathological formation of mature bone in soft tissues, most frequently following trauma, surgery or neurological injury, but also arising in rare genetic ...

In patients with fibrodysplasia ossificans progressiva, an oral selective inhibitor of activin receptor–like kinase 2 was ...

Proposed model for Regulation of BMP Activity by DDR2. After binding collagen, DDR2 alone or together with collagen-binding β1 integrins stabilizes YAP/TAZ nuclear accumulation. This is accomplished ...

For patients with thoracic ossification of the posterior longitudinal ligament (T-OPLL), surgical treatment is effective for improving neurological function, quality of life (QoL), and pain management ...

Bone regeneration research has taken a significant leap forward with the discovery of a crucial mechanism that could transform treatments for bone disorders. Scientists have identified how Discoidin ...

A study conducted by researchers from the Museum für Naturkunde in Berlin revealed the evolution of ossification patterns in the backbones of four-legged vertebrates. Antoine Verrière and his ...

In a study published in Cell Research, researchers have identified a fibrous-layer resident subpopulation of P-SSCs labeled by Angptl7. They found that these cells are crucial for bone fracture repair ...

image: Tppp3+ tendon sheath progenitors expand at the heterotopic ossification (HO) induction site after Achilles tendon injury. a Schematic representation of HO induction, including complete Achilles ...