The Seattle Seahawks will take on the San Francisco 49ers for the third time this year. Seattle bookended the 2025 regular season with games against San Francisco in Weeks 1 and 18, and now they'll have to face them in the Divisional Round of the playoffs. A little scheduling quirk, considering the Niners were the last team the Seahawks played.

The 49ers, the No. 6 seed in the NFC, won 23-19 at Philadelphia on Sunday in the wild card round to advance, and as the lowest seed to move on to the divisional round, they'll head to Seattle. Had the Eagles won, the Seahawks would have hosted the fifth-seeded Rams, but instead the Rams will head to Chicago to face the Bears, the NFC's No. 2 seed.

After 272 games of an entertaining regular season, only 14 teams out of 32 remain on the hunt for the Lombardi Trophy.

NFL playoff odds, picks, predictions, TV channel, streaming information for Saturday football game between Seattle Seahawks and San Francisco 49ers.