The endoplasmic reticulum (ER) and the secretory pathway are central to the orchestration of intracellular protein trafficking and lipid homeostasis. These dynamic systems comprise a network of ...
Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson’s disease protein
Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...
Top panels: Root epidermal cells expressing Venus-VAMP727 and mRFP-VAMP721 in wild type (left) and the snx1 mutant (right). The punctate localization pattern of VAMP721, which functions in the ...
News Medical on MSN
New research shows how cells orchestrate protein production
Researchers at HHMI's Janelia Research Campus have uncovered a novel way that two of the structures inside cells—the endoplasmic reticulum (ER) and lysosomes—coordinate the production of proteins, ...
Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...
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