“WARNING: DO NOT Hammer on this mechanism” sounds like the start of a side quest. A quest is exactly what [CelGenStudios] started when he came upon a strange box with this message. The military ...

The immune system is a major target for cancer treatments. Immune checkpoint inhibitors and CAR-T cell therapy can dramatically improve outcomes for many cancers. But for about 70% of patients, these ...

Jigang Wang and colleagues have made significant progress in unraveling the antimalarial mechanisms of artemisinin (ART) and its derivatives. Their latest research, published in the journal ...

Adjuvants are indispensable components of vaccines. Despite being widely used in vaccines, their action mechanisms are not yet clear. With a greater understanding of the mechanisms by which the innate ...

Since its inception, network pharmacology has made significant progress in analyzing drug–disease interactions through biological networks, particularly in interpreting the multi-component, ...

Scientists at St. Jude Children's Research Hospital have used cryo-electron microscopy to generate ten structures of URAT1, a protein linked to gout. Gout is a type of arthritis caused by excess urate ...

Cas13a consists of two lobes—the recognition (REC) and nuclease (NUC) domains—and is guided by a crRNA (50–58 nt) comprising a direct repeat sequence followed by a spacer region. Under the canonical ...

Antibody-drug conjugates (ADCs) have reshaped the cancer treatment landscape across a variety of different tumor types. ADCs' peculiar pharmacologic design combines the cytotoxic properties of ...