Scientists discovered why some neurons resist tau toxicity, identifying CRL5SOCS4 as a crucial defense and linking ...

New research shows how some brain cells fight tau buildup in Alzheimer’s, pointing to internal systems that help neurons survive longer.

In Alzheimer’s disease and other dementias, a protein called tau can pile up inside brain cells and form toxic clumps. Those ...

Early in Alzheimer’s disease, phospho groups modify tau at multiple sites. What controls this process? In the July 6 Science Advances, researchers led by Arne Ittner at Flinders University, Adelaide, ...

In tauopathies, scientists tend to focus on neuronal tau. They track its pathology and blame it for dysfunctional microglia. Now, researchers led by Celeste Karch at Washington University, St. Louis, ...

Researchers have identified OTULIN, an immune-regulating enzyme, as a key trigger of tau buildup in the brain. When OTULIN was disabled, tau vanished from neurons and brain cells remained healthy. The ...