New research linking telomere shortening to myelodysplastic syndromes (MDS) offers substantial therapeutic implications for affected patients and MDS research. In a previous study, the current authors ...

Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice.

Telomere shortening, a chromosomal feature associated with cellular aging, is accelerated in immune cells from patients with rheumatoid arthritis (RA) compared with cells from healthy controls; ...

In the quest to unlock the secrets of aging and longevity, telomeres have emerged as key players. These protective caps at the ends of our chromosomes play a critical role in cellular aging. With each ...

Telomeres, the non-coding ends of linear chromosomes, are thought to be an important mechanism of individual variability in performance. Research suggests that longer telomeres are indicative of ...

Imagine your DNA as a set of shoelaces. Telomeres are like the plastic tips at the ends of those shoelaces, preventing them from fraying and unraveling. Structurally, telomeres are repetitive ...

The stem terminus element (STE), which was discovered 13 y ago in human telomerase RNA, is required for telomerase activity, yet its mode of action is unknown. We report that the Schizosaccharomyces ...

Wrinkles may betray our age externally, but our cells divulge their age -- and chronicle life’s toll -- at the tips of our chromosomes. These tips, called telomeres, may also foretell our risk of ...