The lytic and lysogenic cycles are the two main phases of a virus’ infective lifecycle and route to replication. The lytic cycle, or virulent infection, involves a virus taking control of a host cell ...

When viral DNA is more “liquidy,” it is more easily injected into host cells—so easily, in fact, that multiple virus-carrying capsids may squeeze their DNA payloads into a host cell simultaneously.

A new study reveals a previously unknown mechanism that governs whether viruses that infect bacteria will quickly kill their hosts or remain latent inside the cell. The discovery, reported in the ...

Phase I clinical and pharmacokinetic (PK) trial of the kinesin spindle protein (KSP) inhibitor MK-0731 in cancer patients No significant financial relationships to disclose. This is an ASCO Meeting ...

The oncogenic herpesvirus (HHV8 or KSHV) causes a cancer known as Kaposi's Sarcoma. An international team of scientists led by the University of Helsinki has discovered key factors that control the ...

Several Proteins that Localize to PML-NBs Repress the Transcription of Herpesvirus Lytic Phase Genes & Inhibit their Productive Replication Cycles In summary, HSV-1 and HCMV use similar strategies to ...

In a recent study published in the journal PLoS Pathogens, researchers analyze prophages of the LF82 strain of adherent-invasive Escherichia coli (AIEC) to better understand their behavior in vitro ...

All available evidence indicates that PML-NB proteins associate with HSV-1 and HCMV genomes at the very beginning of both lytic and quiescent infections, and implies that this association is also ...