Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism
Mitochondrial aconitase is sensitive to oxidative inactivation and can aggregate and accumulate in many age-related disorders. Here we report that Lon protease, an ATP-stimulated mitochondrial matrix ...
Under stress circumstances, proteins are at risk of being inactivated by misfolding, unfolding, or aggregation. Protein quality control (PQC) system, chaperones and proteases, safeguards the function ...
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