A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

Scientists at UCL have discovered a novel role played by ribosomes during the folding of new proteins in cells, described in their paper in Nature. Ribosomes, the cell's dedicated molecular machines ...

Just as a misshapen key can't open a lock, the proteins in our cells need to have the correct 3D shape to function properly. And defects in a protein's structure can cause diseases. Proteins are ...