The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.

Although Brock Prudy and the San Francisco 49ers have dealt with many health issues throughout the season, they still find themselves at 9-4. Purdy, even though it may not look the part from a numbers standpoint,

Ricky Pearsall injured his knee on a hip drop tackle in Week 15. We break down the news and provide injury updates.

The 49ers are dominating the Titans, as they should, with a 14-3 lead early in the second quarter. Christian McCaffrey scored the team’s latest touchdown on a 1-yard run to complete a seven-play, 70-yard drive. Jauan Jennings scored the 49ers’ first touchdown on a 4-yard reception from Brock Purdy.

Tennessee Titans' Jeffery Simmons caught his second career TD that trimmed the deficit against the San Francisco 49ers to 31-17.

Another blowout loss for your Tennessee Titans

Tennessee Titans rookie tight end Gunnar Helm was having a good day after scoring his second NFL touchdown against the San Francisco 49ers in Week 15, but thing

The 49ers are 12.5-point favorites, per the latest Titans vs. 49ers odds, and the over/under for total points scored is 44.5 at DraftKings. The 49ers are -901 money line favorites (risk $901 to win $100),