Edwards unsuccessfully ran for the seat twice last year. She faced off against U.S. Rep. Sheila Jackson Lee in the 2024 Democratic primary. Jackson Lee won the primary but died before the general election,

Nominee Amanda Harris watches as the Harris County precinct chairs vote for a new candidate to replace U.S. Rep. Sheila Jackson Lee on November ballot during a meeting on Tuesday, Aug. 13, 2024 in Houston. The precinct chairs voted narrowly for former Houston Mayor Sylvester Turner over Amanda Edwards to replace U.S. Rep. Jackson Lee.

Edwards launched her third bid for the seat in less than two years. She previously waged an unsuccessful Democratic primary challenge to the late U.S. Rep. Sheila Jackson Lee, then lost a bid to replace Jackson Lee on the ballot in the 2024 general election to the late U.