The San Francisco 49ers (9-4) will face the Tennessee Titans (2-11) in Week 15 at Levi’s Stadium, with all eyes on star running back Christian McCaffrey. McCaffrey was a late addition to the injury report on Saturday with a back issue, earning a questionable designation.

The Tennessee Titans and the San Francisco 49ers meet Sunday in Week 15 in Santa Clara, California, with kickoff slated for 4:25 p.m. ET.

The Titans Wire staff offer their picks and predictions ahead of a Week 15 game between the Tennessee Titans and San Francisco 49ers.

See where the San Francisco 49ers stand in Week 15 power rankings as the team comes off its bye week, riding a three-game win streak.

San Francisco 49ers quarterback Brock Purdy is officially out for Sunday's game against the Tampa Bay Buccaneers due to the toe injury that has caused him to miss multiple games already this season. Backup quarterback Mac Jones is listed as questionable ...

The Tennessee Titans and San Francisco 49ers face off in Week 15 action this Sunday at Levi's Stadium. Literally no one expects the Titans to win this game, and it's unlikely the Titans can keep the score close. The 49ers are in the playoff hunt and will be fresh off their bye week, while the Titans are on a different trajectory.

How Week 14 games impact San Francisco's NFC seeding, postseason path, and key rooting interests in a tight playoff race.

Need to know. Brock off a bye. 49ers quarterback Brock Purdy has played two games off a bye in his career, and he has been nearly perfect in both. In those two g

The San Francisco 49ers have had a strong season while overcoming impactful injuries, but Kyle Shanahan says it isn't the team he's most proud of.