Tuberculosis (TB) is a highly complex and variable disease that presents along a spectrum of infection outcomes. The TB granuloma is a primary contributor to the biological heterogeneity of TB. Local ...

One of the main challenges for tuberculosis (TB) therapy is how to deliver drugs to the site of disease. Once the body’s immune system is infected with tuberculosis, it forms granulomas—tight clusters ...

Tuberculosis (TB) causes almost 2 million deaths annually, and an increasing number of patients are resistant to existing therapies. Patients who have TB require lengthy chemotherapy, possibly because ...

Scientists used computers to model the formation of tuberculosis granulomas in the lung -- the non-active (latent) form of infection found in 2 billion individuals worldwide (11 million in the U.S.) ...

MicroCT of infected human lung tissue, along with histology and immunohistochemistry, was used to construct images of TB granulomas, airways and vasculature. For 70 years, clinicians thought they knew ...

Tuberculosis (TB) is one of the major systemic diseases causing mortality and morbidity in developing countries. However, migration from these countries to developed countries, widespread drug abuse, ...

Every year, 10 million people contract tuberculosis (TB), a disease caused by the bacterium Mycobacterium tuberculosis (Mtb), and approximately 1.5 million patients succumb to the disease. Treatment ...

BIRMINGHAM, Ala. – For 70 years, clinicians thought they knew the shape of tuberculosis granulomas in the lungs of patients. Histology — the study of microscopic structures in thin slices of lung ...