eLife

A meta-analysis suggests that TMS targeting the hippocampal network selectively improves episodic memory

Meta-analysis indicates that network-targeted noninvasive brain stimulation consistently enhances memory function supported by the hippocampal network, thus providing robust evidence that specific ...
eLife

Visuomotor mismatch EEG responses in occipital cortex of freely moving human subjects

This valuable study demonstrates that self-motion strongly affects neural responses to visual stimuli, comparing humans moving through a virtual environment to passive viewing. However, evidence that ...
eLife

HoxB-derived hoxba and hoxbb clusters are essential for the anterior–posterior positioning of zebrafish pectoral fins

Vertebrate paired appendages, such as the pectoral fins in fish and the forelimbs in tetrapods, arise at specific regions along the anterior–posterior axis of the body. Hox genes have long been ...
eLife

Non-visual light modulates behavioral memory and gene expression in C. elegans

Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, United States ...
eLife

CNN-based learning of single-cell transcriptomes reveals a blood-detectable multi-cancer signature of brain metastasis

This important study describes a deep learning framework that analyzes single-cell RNA data to identify a tumor-agnostic gene signature associated with brain metastases. The identified signature ...
eLife

Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes

This important study presents a technically rigorous and carefully controlled analysis of the signalling potential of cancer-associated gain-of-function Notch alleles. The work is clearly presented, ...
eLife

Spatially heterogeneous inhibition projects sequential activity onto unique neural subspaces

This valuable study uses mathematical modeling and analysis to address the question of how neural circuits generate distinct low-dimensional, sequential neural dynamics that can change on fast, ...
eLife

The role of co-infection in the pathogenesis of acute SARS-CoV-2 infection and development of post-acute sequelae: A perspective

Unraveling mechanisms underlying post-acute SARS-CoV-2 sequelae (long COVID) and finding therapeutic solutions require a full understanding of the causative role of SARS-CoV-2 persistence and/or ...
eLife

Mother-child dyadic interactions shape the developing social brain and Theory of Mind in young children

Children’s social cognitive development emerges from the dynamic interplay of neural maturation, parental caregiving, and dyadic brain-to-brain synchrony.
eLife

Multi-barrier unfolding of the double-knotted protein, TrmD–Tm1570, revealed by single-molecule force spectroscopy and molecular dynamics

This study investigates the folding and unfolding behavior of the doubly knotted protein TrmD-Tm1570, providing insight into the molecular mechanisms underlying protein knotting. The findings reveal ...
eLife

Synaptic density and relative connectivity conservation maintain circuit stability across development

The authors have performed a potentially valuable new kind of analysis in connectomics, mapping to an interesting developmental problem of synaptic input to sensory neurons. While the analysis itself ...
eLife

Quantifying the shape of cells, from Minkowski tensors to p-atic orders

Only rigorous mathematical tools to quantify the shape of cells can guarantee reliable results in coarse-grained descriptions of tissue dynamics.